Jung, personal communication. You'll be in good company. Journal of Lipid Research. Previous Section Next Section. Plasmids The cloning strategy employed throughout these studies involved cloning of fragments of interest into several vectors that contain a CpoI site inserted into each polylinker. Immunoprecipitation and Immunoblotting The procedures used have been described In Vitro Histone Binding Binding reactions were carried as described 6 , Previous Section.
Cesarman E. Semin Cancer Biol. CrossRef Medline Google Scholar. Wong E. Medline Google Scholar. Schulz T. Ganem D. Listening to human biology and medicine. Sun R. Izumiya Y. Chang P. Cancer Res. Toth Z. PLoS Pathog. PLoS Pathog 6 , e Kedes D. Mesri E. Cancer 10 , — Verma S.
Lim C. Grundhoff A. Han S. Kelley-Clarke B. Lan K. Platt G. Radkov S. Murakami Y. Friborg J. Nature , — Varjosalo M. Cell , — Cheng F. Ohsaki E. Bedford M. Who, what, and why. Gary J. Nucleic Acid Res. Boisvert F. Proteomics 2 , — Koyuncu O. Iacovides D. Shire K. Mears W. Hibbard M. Xie B. Rho J. Hamza M. Direct interaction with cyclin-CDK2 and induction of G 1 growth arrest. Physical association and promoter-dependent transcriptional repression.
Herndier B. AIDS 8 , — Siegal B. Possibly the result of a dual viral infection. Cancer 65 , — Virus Res , 74 — Buchholz F. Nakamura H. Barbera A. Science , — Lee J. Cell 18 , — Piolot T. Mostaqul Huq M. EMBO J. Vieira J.
Virology , — Copeland N. A powerful new tool for mouse functional genomics.
- Tigers Tale?
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Arad U. Biotechniques 24 , — Yun M. Cell Res. Robin-Lespinasse Y. Cell Sci. Paulette F. Ajithdoss, Lucy F. Reddy Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens. Virology share first authorship. Ellison, Paul A. Thomas J. Ajithdoss, Oren Gilad, Lucy F. Journal of Virology share first authorship. Pei-Ching Chang, Latricia D. Ann, Paul A. Cancer Research Oliver Gautschi, Clifford G. Tepper, Phillip R. Purnell, Yoshihiro Izumiya, Christopher P. Evans, Tim P. Green, Pierre Y.
Desprez, Primo N. Lara, David R. Gandara, Philip C.
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Journal of Virology Alon M. Witter, Lucy F. Lee, Carol J. Furthermore, the microPeptide-mediated manipulation of protein function that adds a new dimension of biological regulation is on the horizon Jaber and Yuan, Second, increasing evidence suggests that contributions of KSHV lytic life cycle to oncogenesis are far greater than what we thought before. Is KSHV reactivation and lytic replication required for tumorigenesis by increasing viral titer to facilitate viral dissemination to the sites of tumor? At least 12 KSHV lytic proteins have been demonstrated to involve oncogenesis including transforming, pro-angiogenic, pro-growth, anti-apoptotic, or immuno-modulatory functions.
Do these viral lytic proteins thus serve as direct effectors of the disease phenotypes and do lytically infected cells serve not only as reservoirs of infectious virus but also as reservoirs of pathogenic viral proteins? Research on these questions will provide novel insights into pathogenesis of tumor viruses.
There is currently no definitive cure for KS. Classic cancer therapies are generally used to treat KS patients, which include surgical excision and radiation therapy for patients with a few lesions in a limited area and chemotherapy for patients with extensive or recurrent KS Antman and Chang, However, these therapeutic agents do not target the etiological virus and the tumor response to any chemotherapeutic regimen is only transient.
However, currently there are no effective drugs targeting KSHV available. For example, RTA is unique transcription factor. Its DNA binding region does not contain any well-characterized DNA binding motifs and the overall protein shows no homology with any known cellular transcriptional activators. Therefore, RTA is an attractive target for antiviral therapy. In addition, virion assembly and egress processes are expected to be effective targets for broad-spectrum antiviral drugs.
KA and YY contribute to the writing, figure-making, and proofreading for this review article.
Kaposi Sarcoma Herpesvirus: New Perspectives (Hardcover, 2007 ed.)
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. Aksyuk, A. Subassemblies and asymmetry in assembly of herpes simplex virus procapsid. Anders, D.
Arvin, G. Campadelli-Fiume, E. Mocarski, P. Moore, B. Roizman, R. Whitley, et al. Cambridge: Cambridge University Press , Google Scholar. Antman, K. Aoki, Y. Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders. Blood 97, — Arvey, A. An atlas of the Epstein-Barr virus transcriptome and epigenome reveals host-virus regulatory interactions. Cell Host Microbe 12, — AuCoin, D. Virology , — Ballestas, M. Science , — Bechtel, J. Bellare, P. Regulation of KSHV lytic switch protein expression by a virus-encoded microRNA: an evolutionary adaptation that fine-tunes lytic reactivation.
Cell Host Microbe 6, — Bhatt, A. Bortz, E. Murine gammaherpesvirus 68 ORF52 encodes a tegument protein required for virion morphogenesis in the cytoplasm. Boshoff, C. AIDS-related malignancies. Cancer 2, — Bourboulia, D. Short-and long-term effects of highly active antiretroviral therapy on Kaposi sarcoma-associated herpesvirus immune responses and viraemia.
AIDS 18, — Bower, M. Brown, H. Brulois, K. Bu, W. Cai, J. Cai, Q. PLoS Pathog. Cai, X. Candido, E. Sodium butyrate inhibits histone deacetylation in cultured cells. Cell 14, — Cannon, M. The KSHV G protein-coupled receptor signals via multiple pathways to induce transcription factor activation in primary effusion lymphoma cells. Oncogene 23, — Carroll, K. Caselli, E. Casper, C. Blood , — PubMed Abstract Google Scholar.
HIV infection and human herpesvirus-8 oral shedding among men who have sex with men. Immune Defic. Cattelan, A. Cancer Inst. Cesarman, E. Challberg, M. Animal virus DNA replication. Chang, H. Chang, J. Virology , 17— Chang, M. Chang, P. Cancer Res. Chang, Y. Chaudhary, P. Oncogene 18, — Chen, D. Virology , 10— Chen, H. Chen, J. Chen, M. Oncotarget 7, — Cheong, W. Downregulation of Poly ADP-Ribose Polymerase 1 by a viral processivity factor facilitates lytic replication of gammaherpesvirus. Cohen, A.
Cole, S. Psychological risk factors for HIV pathogenesis: mediation by the autonomic nervous system. Psychiatry 54, — Dai, W. Unique structures in a tumor herpesvirus revealed by cryo-electron tomography and microscopy. Dai, X. Davis, D. Hypoxia induces lytic replication of Kaposi sarcoma-associated herpesvirus. Davis, Z. Global mapping of herpesvirus-host protein complexes reveals a transcription strategy for late genes. Deng, B. DePamphilis, M. Origins of DNA replication that function in eukaryotic cells.
Cell Biol. Di Bartolo, D. Ehrlich, E. Epelbaum, O. Lung , — Feske, S. Fruehauf, J. Reactive oxygen species: a breath of life or death? Giffin, L. KSHV: pathways to tumorigenesis and persistent infection. Virus Res. Gil, L. Gonzalez-Molleda, L. Antimicrobe Agents Chemother. Goodwin, D. Herpesvirus saimiri open reading frame 50 Rta protein reactivates the lytic replication cycle in a persistently infected A cell line.
Gottwein, E. Cell Host Microbe 10, — Viral and cellular microRNAs as determinants of viral pathogenesis and immunity. Cell Host Microbe 3, — A viral microRNA functions as an ortholog of cellular miR Nature 13, — Gould, F. Gradoville, L. Gregory, S. Toll-like receptor signaling controls reactivation of KSHV from latency. Griffin, L. Grundhoff, A. Inefficient establishment of KSHV latency suggests an additional role for continued lytic replication in Kaposi sarcoma pathogenesis. Guasparri, I. Guihot, A. Guito, J. KSHV Rta promoter specification and viral reactivation.
KSHV reactivation and novel implications of protein isomerization on lytic switch control. Viruses 7, 72— Gunther, T. The epigenetic landscape of latent Kaposi sarcoma- associated herpesvirus genomes. Guo, H. Open reading frame 33 of a gammaherpesvirus encodes a tegument protein essential for virion morphogenesis and egress. Gwack, Y. Haque, M. Harrington, W. Lancet , — Harrison, S. FEBS Lett. Homa, F. Huang, L. Reciprocal regulatory interaction between human herpesvirus 8 and human immunodeficiency virus type 1. Hyun, T. Iroezindu, M. Health Sci.
Izumiya, Y. Jaber, T. Jiang, Y. Johnson, P. Nucleic Acids Res.
- Kaposi's Sarcoma-Associated Herpesvirus-Related Solid Lymphoma Involving the Heart and Brain.
- Peep, the Hundred-Decibel Hummer.
Jones, J. Kang, H. Karijolich, J. Keller, R. Kimball, L. Reduced levels of neutralizing antibodies to Kaposi sarcoma-associated herpesvirus in persons with a history of Kaposi sarcoma. King, C. Konrad, A. Lambert, M. Lan, K. Lebbe, C. Lee, C. Lei, X. Lepone, L. Vaccine Immunol. Li, D. Li, Q. Li, W. Li, X. Liang, Y. Genes Dev.
Lieberman, P. Keeping it quiet: chromatin control of gammaherpesvirus latency. Lin, C.